A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation
نویسندگان
چکیده
منابع مشابه
Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.
Platelets are essential in maintaining hemostasis following inflammation or injury to the vasculature. Dysregulated platelet activity often results in thrombotic complications leading to myocardial infarction and stroke. Activation of the FcγRIIa receptor leads to immune-mediated thrombosis, which is often life threatening in patients undergoing heparin-induced thrombocytopenia or sepsis. Inhib...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2018
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2018.189365